Many nutritional supplementation companies have jumped on the bandwagon of increasing the time between Vitamin D doses due to the fact that it is fat soluble and able to be stored for long periods of time . Water soluble vitamins, such as Vitamin C, are not stored and excess is excreted via the urine. Vitamin D is stored in both your fat tissue and your liver and can be accessed as your body needs. However, since it is fat soluble and can be stored you must be careful as to not consume too much vitamin D and reach levels of toxicity.
For the most part, Americans suffer from an epidemic of vitamin D deficiency so toxicity is usually the last thought in the minds of the clinician or the patient. However, as Vitamin D doses are now available in the 50,000 or 100,000IU range, one can quickly reach levels of toxicity.
Another factor to consider is with the rare Vitamin D dose of once per week, month or quarter, we see an decrease in patient compliance because it is harder to remember the occasional dose schedule.
A recent study in Clinical Endocrinology in Feb 2016, gave patients doses of 100 000 or 200 000 IU of oral cholecalciferol every 3 months and they were not capable of stabilizing 25OHD levels over the target of 75 nmol/L over the year. The researchers concluded the study with the following recommendation, “to improve the efficacy of high-dose vitamin D therapy the interval between boluses has to be shortened instead of increasing their size.”
Aceva provides liquid Vitamin D drops that include K2 to help drive the calcium absorbed to musculoskeletal tissue instead of organ tissue and Vitamin tablets that are 5,000IU per capsule and contain Vitamin K2 as well as all the additional cofactors necessary to convert to the active form of vitamin D.
Välimäki, V. V., Löyttyniemi, E., Pekkarinen, T., & Välimäki, M. J. (2016). How well are the optimal serum 25OHD concentrations reached in high‐dose intermittent vitamin D therapy? a placebo‐controlled study on comparison between 100 000 IU and 200 000 IU of oral D3 every 3 months in elderly women. Clinical endocrinology.